%0 Journal Article
%T Heat and hyposmotic stimulation increase in [Ca2+]i by Ca2+ influx in rat synoviocytes<br>Heat and hyposmotic stimulation increase in [Ca^2＋]i by Ca^2＋ influx in rat synoviocytes
%A WenWu Sun
%A Fen Hu
%A WenXiu Yang
%A <br>
%J 科学通报(英文版)
%D 2008
%I 
%X Rheumatoid arthritis (RA), which is marked by inflammatory synovitis, is a common, chronic autoimmune-disease, whose pathogenesis is complex and still unclear. In order to explore the effects of heat and hyposmotic stimuli on synoviocytes in rheumatoid arthritis, the changes of Ca2+]i induced by heat, hyposmotic and 4α-PDD stimuli were observed in synoviocytes. Ca2+]i elevation induced by heat   28, hyposmotic and 4α-PDD stimuli is found to be positively relative to increasing temperature, decreasing osmolality and rising concentration of 4α-PDD. Results show that there is reciprocity among these stimuli and desensitization, and that Ca2+]i elevation depends on Ca2+ influx, but not necessarily links to Ca2+ release from intracellular stores and voltage-dependent Ca2+ channel in synoviocytes. The above characteristics of Ca2+ influx are similar to those of TRPV4. A probable mechanism has been suggested that heat and hyposmotic stimulation might increase the level of Ca2+]i by activating the TRPV4-like channel and Ca2+ influx in the synoviocytes. Supported by a foundation of the City of Tianjin, China (Grand No. 983113411)
%K synoviocyte
%K heat
%K hyposmolality
%K 4α
%K -PDD
%K [Ca2+]i<br>synoviocyte
%K heat
%K hyposmolality
%K 4α-PDD
%K [Ca2
%K ]i
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=31985F72C94118B9B5086BE11E8996BD&yid=67289AFF6305E306&vid=8E6AB9C3EBAAE921&iid=E158A972A605785F&sid=E5D85F291CED2DA6&eid=D8414BC1307BF1A3&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=26