%0 Journal Article
%T A novel strategy for cancer treatment: Targeting cancer stem cells<br>A novel strategy for cancer treatment:Targeting cancer stem cells
%A Jia Liu
%A LeiNa Ma
%A YiGang Wang
%A XinYuan Liu
%A QiJun Qian
%A <br>
%J 科学通报(英文版)
%D 2008
%I 
%X Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule in- hibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a signifi- cant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors.Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal,a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment.
%K cancer stem cell
%K targeting
%K oncolytic adenovirus
%K strategy<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=C3B79B9A0AF9A104B2E8A2661FF28962&yid=67289AFF6305E306&vid=8E6AB9C3EBAAE921&iid=59906B3B2830C2C5&sid=E0606BDC3B7A10F0&eid=5B3A9A8E2DA941E3&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=1&reference_num=64