%0 Journal Article
%T Triphenyltin inhibition of the proteasome activity and its influence on substrate protein levels in nerve cells<br>
%A Xi Chen
%A GuoQing Shi
%A GuangRong Zhong
%A Juan Chen
%A Sen Lin
%A Qing Sun
%A <br>
%J 科学通报(英文版)
%D 2010
%I 
%X Triphenyltin (TPT) widely exists as environmental pollutant, but its toxicity towards nerve cells and the related mechanism re-main unclear. In this research, SHSY-5Y cells were exposed to TPT, and the cellular proteasome activity, Iκb proteins, Bax and κ-synuclein levels were investigated. The results show that TPT can inhibit the cellular proteasome activity, and result in the ac-cumulation of ubiquitinized proteins. TPT exposure can change the protein levels of IκB, Bax, and α-synuclein, affect NFκB path-way, activate the process of cell death, and induce α-synuclein aggregation. Our results indicate that TPT exposure can lead to neuotoxzcity.
%K triphenyltin
%K proteasome
%K &alpha
%K -synuclein
%K Parkinson&rsquo
%K s disease<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=AF25004C7DCD16AF16ECCC9E73ACC39A&yid=140ECF96957D60B2&vid=E514EE58E0E50ECF&iid=CA4FD0336C81A37A&sid=BC12EA701C895178&eid=96C778EE049EE47D&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=27