%0 Journal Article
%T Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer<br>
%A JingYi Rao
%A ZhiYuan Zhu
%A ShiYong Liu
%A <br>
%J 科学通报(英文版)
%D 2009
%I 
%X Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits “schizophrenic” micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD). Supported by the National Natural Science Foundation of China (Grant Nos. 20534020, 20674079, and 20874092)
%K poly(L-glutamic acid)
%K poly(propylene glycol)
%K coil
%K α
%K -helix
%K micellization<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=AB90848131612AD9E5BF532DBEAB593E&yid=DE12191FBD62783C&vid=318E4CC20AED4940&iid=708DD6B15D2464E8&sid=E1E3BF53C3583450&eid=7D3E890216EEDC54&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=36