%0 Journal Article
%T Pulsed Amperometry for Anti-fouling of Boron-doped Diamond in Electroanalysis of ¦Â-Agonists: Application to Flow Injection for Pharmaceutical Analysis
%A Chanpen Karuwan
%A Thitirat Mantim
%A Patcharin Chaisuwan
%A Prapin Wilairat
%A Kate Grudpan
%A Piyada Jittangprasert
%A Yasuaki Einaga
%A Orawon Chailapakul
%A Leena Suntornsuk
%A Oraphan Anurukvorakun
%A Duangjai Nacapricha
%J Sensors
%D 2006
%I MDPI AG
%R 10.3390/s6121837
%X This work presents the construction and application of boron-doped diamond(BDD) thin film electrode as sensor for the determination of three ¦Â-agonists, viz.salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inertmaterial, BDD film however shows fouling in detection of these compounds using fixedpotentialmode amperometry. A suitable waveform for pulsed amperometric detection(PAD) was developed and used to determine the agonist compounds. It was seen that thedeveloped PAD significantly refreshed the BDD surface for long-term detection in flowinjection analysis. Linear working ranges were 0.5-100 ¦ÌM, 1.0-100 ¦ÌM and 0.5-50 ¦ÌM forsalbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system wasapplied to successfully determine salbutamol and terbutaline in commercial pharmaceuticalproducts. The methods were validated with a capillary electrophoresis method.
%K boron-doped diamond
%K pulsed amperometry
%K ¦Â-agonists
%K flow injection
%U http://www.mdpi.com/1424-8220/6/12/1837