%0 Journal Article
%T Non-viral gene delivery carrier of probe type host molecule—Interactions between DNA and β-cyclodextrin derivative complexes (I)<br>Non-viral gene delivery carrier of probe type host molecule ——Interactions between DNA and β-cyclodextrin derivative complexes (I)
%A LIU Tao
%A CHEN Long
%A HOU Sen
%A XUE Yonglai
%A FENG Xizeng
%A <br>LIU
%A Tao
%A CHEN
%A Long
%A HOU
%A Sen
%A XUE
%A Yonglai
%A FENG
%A Xizeng
%J 科学通报(英文版)
%D 2006
%I 
%X A host type non-virus gene delivery carrier, phenanthroline-β-cyclodextrin derivative host molecule, was produced which can be used as molecular probe. Interactions between DZY-1 and DNA were investigated by electrophoresis assay. Hind III enzyme inhibition assay was carried out using DNA condensates induced by host molecules or host-guest molecule complexes to explore their ability to inhibit enzyme digestion. Micro-structure of DNA condensates induced by host molecules and host-guest molecule complexes was observed by scanning electron microscope (SEM). Our work indicates the delivery mechanism of DZY-1 used as a gene delivery carrier and also provides a method to design and produce non-virus gene delivery carriers.
%K phenanthroline-β
%K -cyclodextrin derivatives (DZY-1)
%K λ
%K -DNA
%K non-virus gene delivery carrier
%K agarose gel electrophoresis
%K scanning electron microscope (SEM)<br>phenanthroline-β-cyclodextrin
%K derivatives
%K (DZY-1)
%K λ-DNA
%K non-virus
%K gene
%K delivery
%K carrier
%K agarose
%K gel
%K electrophoresis
%K scanning
%K electron
%K microscope
%K (SEM).
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=D8006B6800AC495FF7B52AEDD5B081ED&yid=37904DC365DD7266&vid=987EDA49D8A7A635&iid=94C357A881DFC066&sid=BB98BB04E861B6F5&eid=A726E84831FE609B&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=13