%0 Journal Article
%T Surface modification of nanogold particles in DNA detection with quartz crystal microbalance
%A LIU Tao
%A TANG Jian
%A HAN Meimei
%A JIANG Long
%A <br>LIUTao
%A TANGJi＇an
%A HANMeimei
%A JIANGLong
%J 科学通报(英文版)
%D 2003
%I 
%X Nanogold particles in different sizes, from 5 to 60 nm, were utilized to modify the surface of the quartz crystal microbalance (QCM). It was found that the gold-particle size of the modified QCM affects both the amount of the immobilization of the probe on the surface of QCM and the hybridization rate of the target DNA. 20 nm was determined to be the optimal size for the surface modification and it can maximally increase the sensitivity of the DNA detection.
%K gold nanoparticle
%K DNA detection
%K quartz crystal micro-balance<br>石英晶体微量天平
%K 表面修复
%K DNA探测
%K 金
%K 纳米粒子
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=107A3E76BDB46165C0B4C22B439201C7&yid=D43C4A19B2EE3C0A&vid=B6DA1AC076E37400&iid=9CF7A0430CBB2DFD&sid=BF1420E7E18952EE&eid=4AA5FA7F666BDD0A&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=2&reference_num=12