%0 Journal Article
%T Effect of PKC pathway on G1 /S progression control in HeLa cells<br>Effect of PKC pathway on G1/S progression control in HeLa cells
%A HU Jiang
%A LIU Huitu
%A <br>
%J 科学通报(英文版)
%D 2000
%I 
%X The effect of PKC activity on G1/S progression in HeLa cells has been studied. The result shows that (i) PKC activity alteration in G1 phase affects G1/S progression in HeLa cells. It has been observed that G1/S progression is stimulated by PKC agonist TPA and inhibited by PKC inhibitor GF-109203X. (ii) The expression ofc-myc andc-jun is stimulated by TPA and inhibited by GF-109203X treatment in early G1 phase. (iii) During G1/S progression, the expression of CyclinD1 is stimulated by TPA treatment and inhibited by GF-109203X treatment. There is no effect on the expression of CDK4. It is likely that PKC pathway regulates G1/S progression through regulating the expression of some early response genes and engine molecules in HeLa cells.
%K PKC
%K cell cycle
%K early response gene
%K engine molecules<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=2F90E3A04267DE42&yid=9806D0D4EAA9BED3&vid=94E7F66E6C42FA23&iid=94C357A881DFC066&sid=78976D931AD1540F&eid=D98387EFB283C5E0&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=7