%0 Journal Article
%T Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells (MSCs) on poly DL-lactic-co-glycolic acid (PLGA) films<br>Proliferation and differentiation into endothelial cells of human bone marrow mesenchymal stem cells （MSCs） on poly DL-lactic-co-glycolic acid （PLGA） films
%A Yue Huimin
%A Zhang Lei
%A Wang Yunfang
%A Liang Feng
%A Guan Lidong
%A Yan Fang
%A Nan Xue
%A Bai Cixian
%A Lin Feng
%A Yan Yongnian
%A Pei Xuetao
%A <br>YUE
%A Huimin
%A ZHANG
%A Lei
%A WANG
%A Yunfang
%A LIANG
%A Feng
%A GUAN
%A Lidong
%A Li
%A Shaoqing
%A YAN
%A Fang
%A NAN
%A Xue
%A BAI
%A Cixian
%A LIN
%A Feng
%A YAN
%A Yongnian
%A PEI
%A Xuetao
%J 科学通报(英文版)
%D 2006
%I 
%X The functional realization is the most important problem in vascular tissue engineering. The small-caliber blood vessel substitutes are prone to thrombi, which results in functional loss of blood vessels. However, this is probably due to the imperfection of endothelial layer in the substitutes. In this study, MSCs were seeded on a series of porous PLGA films with various porosity and pore size made by sodium chloride (NaCl) particulate leaching, and cell proliferation on each film was inspected. The film made of the 75% (w/w) particulate proportion and 30–50 μm pore size maximized the proliferation rate and was chosen as the scaffolds for the differentiation of MSCs into endothelial cells. The induced cells expressed endothelial cells specific Flk-1, VIII factor and CD34, possessed endothelial cells specific Weible-palade (W-P) body, and had the abilities of ingesting low density lipoprotein and secreting prostacyclin (PGI2). The results show that MSCs not only have the ideal biological compatibility with the porous PLGA films, but also have the potency of differentiating into functional endothelial cells, which should facilitate the endothelialization in vascular tissue engineering. These authors contributed equally to this work.
%K MSCs
%K PLGA
%K differentiation
%K endothelial cells
%K endothe- lialization
%K vascular tissue engineering<br>MSCs
%K PLGA
%K 内皮细胞
%K 内皮化
%K 维管组织工程
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=3117CB4E3E01DDFF0F7531845C07BD76&yid=37904DC365DD7266&vid=987EDA49D8A7A635&iid=708DD6B15D2464E8&sid=F016DE22306D4D4A&eid=FC9A32AA461904A5&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=11