%0 Journal Article
%T Permeation study of the potassium channel from streptomyces Lividans
%A Xiuzhi Xu
%A Yong Zhan
%A Tongjun Zhao
%A <br>XUXiuzhi
%A ZHANYong
%A ZHAOTongjun
%J 科学通报(英文版)
%D 2004
%I 
%X A three-state hopping model is established ac-cording to experiments to study permeation of an open-state potassium channel from Streptomyces Lividans (KcsA po-tassium channel). The master equations are used to charac-terize the dynamics of the system. In this model, ion conduc-tion involves transitions of three states, with one three-ion state and two two-ion states in the selectivity filter respec-tively. In equilibrium, the well-known Nernst equation is deduced. It is further shown that the current follows Micha-elis-Menten kinetics in steady state. According to the pa-rameters provided by Nelson, the current-voltage relation-ship is proved to be ohmic and the current-concentration relationship is also obtained reasonably. Additional valida-tion of the model in the characteristic time to reach the steady state for the potassium channel is also discussed. This model lays a possible physical basis for the permeation of ion channel, and opens an avenue for further research.
%K master equation
%K ion permeation
%K potassium channel<br>离子渗透
%K 钾离子通道
%K 三阶跳跃方程
%K 离子传导
%K 链霉菌
%K 跨膜蛋白
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=921C50DBB87C67A108903AD5DC493808&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=708DD6B15D2464E8&sid=4814830A427BF9BC&eid=D7B9DD9E919B6180&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=1&reference_num=11