%0 Journal Article
%T α-LTX and α-LTXN4C induce [Ca2+]i elevation through different mechanisms in pancreatic β cells
%A JIU Yaming
%A HU Zhitao
%A LIU Jie
%A WU Zhengxing
%A XU Tao
%A <br>JIU
%A Yaming
%A HU
%A Zhitao
%A LIU
%A Jie
%A WU
%A Zhengxing
%A XU
%A Tao
%J 科学通报(英文版)
%D 2006
%I 
%X α-latrotoxin (α-LTX), a neurotoxin from black-widow spider, causes vesicles release in presynapse of nerve terminal after binding to specific membrane receptors. α-LTXN4C is an effective tool binding to calcium independent receptor for latrotoxin (CIRL), which is used to elucidate the mechanism of receptor-mediated signal pathway. In our study on the pancreatic β cells, we found that α-LTX inserts into the plasma membrane and forms stable non-selective cation channels. The influx of extracellular Ca2+ through the channels causes massive Ca2+-dependent exocytosis of insulin-containing vesicles, whereas, α-LTXN4C, binding with its receptor CIRL in extracellular divalent cation-dependent way, increases Ca2+]i by mobilization of the intracellular calcium stores. These authors contributed equally to the work.
%K α
%K -Latrotoxin
%K α
%K -LTXN4C
%K calcium<br>α-Latrotoxin
%K α-LTXN4C
%K calcium.
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=480642AB3F6B3C6216C0DC650D5B0D5B&yid=37904DC365DD7266&vid=987EDA49D8A7A635&iid=0B39A22176CE99FB&sid=4C100B7696CE9E24&eid=D5C9DC4EF2F78008&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=1&reference_num=26