%0 Journal Article
%T Study on fragmentation behavior of taxoids by tandem mass spectrometry<br>
%A Zeper Abliz
%A FANG Qicheng
%A LIANG Xiaoting
%A Mitsuo Takayama
%A <br>
%J 科学通报(英文版)
%D 2000
%I 
%X We have studied the fragmentation behavior of positive and negative ions of taxol and 6/8/6 type taxoids, the influence of different substituents on fragmentation, and the correlativity between fragmentation patterns and structure by MS/MS technique with different ionization methods such as FAB-MS, ESI-MS, etc. We have also investigated in detail the fragmentation of various molecular-related ions, such as M+H]+, M+Na]+ and M-H]  ions, and the formation pathways of characteristic fragment ions. It has been found that there exists some competing reaction between the loss of C-13 side chain and decomposition by loss of acetic acid. In addition, by comparing CID spectra obtained with low- and high-energy collision, it is seen that CID-MS/MS with low-energy collision is more suitable for the study of the structural analysis of small molecules and drug metabolites. The experimental results demonstrate that MS/MS spectra can reflect more effectively the slight difference of structure between the related compounds and their structural characteristic features than MS spectra, and can also provide a beneficial analysis basis for these kinds of compounds.
%K taxol
%K taxoids
%K tandem mass spectrometry
%K fragmentation behavior<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=C5A8930C906747D3D86FEBD065E9C4E7&yid=9806D0D4EAA9BED3&vid=94E7F66E6C42FA23&iid=5D311CA918CA9A03&sid=2A22E972FD97071B&eid=6CDD207A90CE1EEC&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=16