%0 Journal Article
%T Primary study of a novel Tc-tricarbonyl cocaine ana- logue as the potential DAT imaging agent<br>Primary study of a novel Tc-tricarbonyl cocaine analogue as the potential DAT imaging agent
%A ZHANG Xiaobo
%A ZHU Lin
%A DING Shaoke & LIU Boli Key Laboratory of Radiopharmaceuticals
%A <br>ZHANGXiaobo
%A ZHULin
%A DINGShaoke
%A LIUBoli
%J 科学通报(英文版)
%D 2005
%I 
%X The convenient preparation of organometallic precursor fac-99mTc(CO)3 (H2O)3]+ opens a new route to design new radiopharmaceuticals. Based on this precursor, a new cocaine analogue, Tropyn, is designed and synthesized, and “2+1” mixed-ligands approach is used to prepare a neutral complex 99mTc(CO)3(Tropyn)I]. Biodistribution in mice and rats proves that it has sufficient brain uptake. Rat regional brain biodistribution indicates that the complex is highly concentrated in the striatum (ST) with rapid clearance in the cortex (CT) and hippocampus (HP), which make it valuable for further investigation as the potential Second-Generation DAT imaging agent.
%K fac-[99mTc(CO)3 (H2O)3]+
%K Tc-tricarbonyl
%K Tropyn
%K dopa- mine transporter<br>放射性药品
%K 可卡因
%K 混合配合基
%K 大脑皮层
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=B03635F2262F2D83D626A1AE791CEAE0&yid=2DD7160C83D0ACED&vid=771152D1ADC1C0EB&iid=5D311CA918CA9A03&sid=A67EE05E56DA7F45&eid=231F9A307C169827&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=10