%0 Journal Article
%T Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA of OH/CHA/99<br>Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA of OH／CHA／99
%A Guangqing Liu
%A Zaixin Liu
%A Qingge Xie
%A Yingli Chen
%A Huifang Bao
%A Xiangtao Liu
%A <br>LIUGuangqing
%A LIUZaixin
%A XIEQingge
%A CHENYingli
%A BAOHuifang
%A LIUXiangtao
%J 科学通报(英文版)
%D 2004
%I 
%X The China foot-and-mouth virus (FMDV) iso-late OH/CHA/99 was isolated from swine, which was unable to infect bovine thyroid cells in vitro or to cause typical dis-ease in bovines following intradermal inoculation in the tongue. To enhance antigenicity, replication, maturation and pathogenicity studies of OH/CHA/99, an infectious full- length cDNA clone, designated pBlFMDV, was prepared. The in vitro and in vivo biological properties of the virus derived from pBlFMDV were studied by analyzing antigenicity, plaque morphology and virulence in pigs. The results showed that the virus derived from pBlFMDV had the same biologi-cal properties as the parent strain OH/CHA/99; the full- length infectious cDNA clone, pBlFMDV, will be very useful in studies of the antigenicity, virulence, pathogenesis, matu-ration and replication of FMDV.
%K foot-and-mouth virus
%K OH/CHA/99
%K full-length cDNA
%K infectious clone
%K pBlFMDV<br>OH／CHA／99
%K 全长cDNA
%K 传染性克隆
%K pBIFMDV
%K 口蹄疫
%K FMDV
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=1189983CC90040BC57A7848007A7FD93&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=708DD6B15D2464E8&sid=966760CE8B6E636C&eid=39B73ADA6F3DD05F&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=18