%0 Journal Article
%T Experimental verifications on chemical carcinogenesis, a bifunctional alkylation between DNA interstrands<br>
%A DAI Qianhuan
%A ZHANG Qingrong
%A WANG Lihui
%A PEI Shu
%A WANG Qing
%A QU Bo
%A <br>
%J 科学通报(英文版)
%D 2000
%I 
%X It is evidenced by the filter elution method that two carcinogenic aromatic hydrocarbons, benzoa]pyrene and dibenzoa,h]anthracene, two carcinogenic metal salts, beryllium chloride and cadmium chloride, four carcinogenic aromatic amines, 2-aminofluorene, β-naphthylamine, 4-aminobiphenyl and benzidine, can all induce DNA interStrand and DNA-protein cross-link in L1210 culture. However, under the same condition, the corresponding non-carcinogenic compounds, including benzok]fluorancene, anthracene, magnesium chloride, zinc chloride, α-naphthylamine, 2-aminobiphenyl andm-toluidine, cannot produce any cross-link adducts. All these results are consistent with the di-region theory that carcinogens are bio-bifunctional alkylation agents. This method can also be used to discriminate carcinogens and non-carcinogens.
%K mechanism of chemical carcinogenesis
%K di-region theory
%K DNA interstrand cross-link
%K aromatic amines
%K polycyclic aromatic hydrocarbons
%K beryllium salt
%K cadmium salt<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=C7040047C4854A49596299636ACA0B03&yid=9806D0D4EAA9BED3&vid=94E7F66E6C42FA23&iid=59906B3B2830C2C5&sid=6A12B9FCEF71AE29&eid=E062BF8B95A95FD2&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=12