%0 Journal Article
%T Rapid senescence induced by overexpression of p53 in NIH3T3 cells<br>
%A Jiancheng Hu
%A Ying Lei
%A Xia Hong
%A Zhigang Lu
%A Zhonghe Zhai
%A <br>
%J 科学通报(英文版)
%D 2001
%I 
%X An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene. It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 °C. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.
%K p53
%K p53Val135
%K NIH3T3
%K senescence
%K overexpression<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=87AA8F7B9E87DD92F77B2648357045F3&yid=14E7EF987E4155E6&vid=D997634CFE9B6321&iid=5D311CA918CA9A03&sid=E4BEEBB9A80BC67E&eid=D559883475316B44&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=18