%0 Journal Article
%T Expression of matrix metallo-proteinase-28 in human nor-mal cytotrophoblast cells and a choriocarcinoma cell line,JEG-3<br>
%A ZHANG Jian
%A CAO Yujing
%A LIU Weimin
%A ZHAO Bingshun
%A ZENG Guoqing
%A DUAN Enkui
%A <br>
%J 科学通报(英文版)
%D 2002
%I 
%X There are striking similiarities present between the behavior of invasive placental cells and that of invasive cancer cells. Matrix metalioproteinases (MMPs) are one of the most important mediators. MMP-28, the new member ofMMPs, was sequenced and identified recently. Expression of MMP-28 mRNA and protein in the cytotrophoblast cells anda choriocarcinoma cell line, JEG-3 cell, was conducted by zymography, RT-PCR and Northern blot. There is MMP-28mRNA expression in both the cytotrophoblast cells and JEG-3 cells by RT-PCR. The activity of MMP-28 in cytotrophoblast cells was significantly weaker than that in JEG-3 (P < 0.01) by zymography. Furthermore, mRNA expression of MMP-28 was significantly stronger (P < 0.001) in JEG-3than in human cytotrophoblast cells in a time-dependent way by Northern Blot. Our results suggest that MMP-28 may play a role in some of the tissue-remodeling events associated with normal pregnancy and tumor progression.``
%K cytotrophoblast cell
%K choriocarcinoma cell line
%K JEG-3
%K matrix metaHoproteinases
%K MMP-28<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=A0E805E6BAB63DAC517CEC36C52A8310&yid=C3ACC247184A22C1&vid=F4B561950EE1D31A&iid=9CF7A0430CBB2DFD&sid=20D29EF591CB2C94&eid=FA98B938D085B826&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=15