%0 Journal Article
%T Phenotypic analysis of the medullary-type CD4-CD8+ thymocytes in mice<br>
%A TIAN Tian
%A WANG Hongfang
%A FENG Meifu
%A CHEN Weifeng
%A <br>
%J 科学通报(英文版)
%D 2000
%I 
%X Phenotypic analysis of the medullary-type CD4 CD8+ (CD8SP) thymocytes has revealed phenotypic heterogeneity within this cell population. The phenotype of mature peripheral CDS+T cells is TCRαβ+CD3+Qa-2+HSA 3G11 6C10, whereas in the medullary-type CD8SP thymocytes, 20% are Qa-2+; 33%, HAS; 30%, 3G11; and 70% are 6C10. The disparate expression patterns of these four cell surface markers suggest that medullary-type CD8SP thymocytes may undergo phenotypic maturation process. According to the distribution of these four cell surface markers, six subgroups of CD8SP thymocytes have been identified. The precursor-progeny relationship along with developmental pathway is postulated as follows: 6C10+HSA+3G11 Qa-2→ 6C10+HSA+ 3G11+Qa-2 → 6C10 HSA+3G11+Qa-2 → 6C10 HSA 3G11+Qa-2 → 6C10 HSA 3G11 Qa-2 → 6C10 HA S 3G11 Qa-2+, the cells in the last subgroup exit the thymus and home into periphery.
%K CD4-CD8+ medullary-type thymocytes
%K cell phenotype
%K phenotypic differentiation<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=D3D3C037A36CCF5F72A461A3EF860DB5&yid=9806D0D4EAA9BED3&vid=94E7F66E6C42FA23&iid=38B194292C032A66&sid=E1D946F217E3B046&eid=FE4C96E058BB2280&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=10