%0 Journal Article %T Construction of fine SNP haplotypes and haplotype blocks in 5 genes in the centromere of chromosome 15 in Chinese Han subjects %A Weijun Huang %A Caixia Li %A Suqin Chen %A Jiandong Sun %A Yan Zhou %A Jiqian Fang %A Yiming Wang %A
HUANGWeijun %A LICaixia %A CHENSuqin %A SUNJiandong %A ZHOUYan %A FANGJiqian %A WANGYiming %J 科学通报(英文版) %D 2004 %I %X Recent advances have shown that the majority of the nucleotide variation in human genome is single nucleo- tide polymorphisms (SNPs). Using SNPs each chromosome can be divided into different haplotype blocks, and there are limited common haplotypes in each block. This provides a powerful approach for whole genome scan for disease-asso- ciated genes/variants. However,most data available today are based on the large-scale genomic analyses, data concern- ing individual genes for fine mapping with high density SNPs are relatively lacking. We have sequenced 7 genes and their flanking regions, identified 34 novel SNPs, constructed high density SNP haplotypes and haplotype blocks in 5 genes in the centromeric region of chromosome 15 in 100 Chinese Han subjects. Our results show that there is a great hetero- geneity in the haplotypes and haplotype block structures within and between these genes, which are in close physical proximity Data obtained in this study provide a useful tool for candidate gene approach at the fine scale for identifying disease contributing variants in the genes/regions. %K haplotype %K haplotype-block %K SNP %K genome %K centromeric genes in chromosome 15
单倍体 %K SNP %K 基因组 %K 着丝点基因 %K 染色体15 %K 单核苷酸多态 %U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=0586C33732CB3E7D59BE5D5D19026BD9&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=F3090AE9B60B7ED1&sid=3F10405738B4D004&eid=14B92F3C984CB5EA&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=4&reference_num=15