%0 Journal Article
%T Construction of fine SNP haplotypes and haplotype blocks in 5 genes in the centromere of chromosome 15 in Chinese Han subjects
%A Weijun Huang
%A Caixia Li
%A Suqin Chen
%A Jiandong Sun
%A Yan Zhou
%A Jiqian Fang
%A Yiming Wang
%A <br>HUANGWeijun
%A LICaixia
%A CHENSuqin
%A SUNJiandong
%A ZHOUYan
%A FANGJiqian
%A WANGYiming
%J 科学通报(英文版)
%D 2004
%I 
%X Recent advances have shown that the majority of the nucleotide variation in human genome is single nucleo- tide polymorphisms (SNPs). Using SNPs each chromosome can be divided into different haplotype blocks, and there are limited common haplotypes in each block. This provides a powerful approach for whole genome scan for disease-asso- ciated genes/variants. However,most data available today are based on the large-scale genomic analyses, data concern- ing individual genes for fine mapping with high density SNPs are relatively lacking. We have sequenced 7 genes and their flanking regions, identified 34 novel SNPs, constructed high density SNP haplotypes and haplotype blocks in 5 genes in the centromeric region of chromosome 15 in 100 Chinese Han subjects. Our results show that there is a great hetero- geneity in the haplotypes and haplotype block structures within and between these genes, which are in close physical proximity Data obtained in this study provide a useful tool for candidate gene approach at the fine scale for identifying disease contributing variants in the genes/regions.
%K haplotype
%K haplotype-block
%K SNP
%K genome
%K centromeric genes in chromosome 15<br>单倍体
%K SNP
%K 基因组
%K 着丝点基因
%K 染色体15
%K 单核苷酸多态
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=0586C33732CB3E7D59BE5D5D19026BD9&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=F3090AE9B60B7ED1&sid=3F10405738B4D004&eid=14B92F3C984CB5EA&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=4&reference_num=15