%0 Journal Article
%T Expression and regulation of metalloproteinases-2, -9 and tissue inhibitors of metallo-proteinases in rat corpus luteum<br>
%A YU Xiaoguang
%A LI Qinglei
%A WANG Hongmei
%A LUO Wenxiang
%A SHAO Longjiang
%A NI Jiang
%A ZHU Cheng
%A <br>
%J 科学通报(英文版)
%D 2002
%I 
%X The expression and regulation of metalloproteinases-2, -9 (MMP-2, -9) and their tissue inhibitors TIMP-1, -2, -3 mRNA were studied in this experiment. In the PMSG- hCG primed pseudopregnant rat, MMP-2, -9 mRNA levels were the highest at Day 1, decreased from Day 4, and reached the minimal level at Day 8, then increased at Day 14; no significant changes were observed in TIMP-2 mRNA expression from Day 1 to Day 14; TIMP-3 mRNA expression was the lowest at Day 1, increased from Day 4, reached the maximal level at Day 8, and persisted to Day 14. TNF-αcould significantly increase the expression of MMP-2, -9 and TIMP-1 mRNA in the in vitro perfused pseudopregnant CL, and decrease the expression of TIMP-3 mRNA, but had no effect on TIMP-2 mRNA expression. The results indicate that MMP-2, -9 and TIMP-1, -2, -3 might be involved in the regulation of CL function and maintenance of CL structure via their coordinated gene expression. TNF-α could inhibit luteal regression via increasing MMP-2, -9 and TIMP-1 mRNA in the in vitro perfused pseudopregnant ovary.
%K matrix metalloproteinases
%K tissue inhibitors of metalloproteinases
%K mRNA
%K corpus luteum
%K ovary perfusion<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=F52A31C1CC781A67396D417431373ABE&yid=C3ACC247184A22C1&vid=F4B561950EE1D31A&iid=59906B3B2830C2C5&sid=BCE65990EF9348F5&eid=512771C17A2FFC1B&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=23