%0 Journal Article
%T Electrochemical Interrogation of Interactions between Surface-Confined DNA and Methylene Blue
%A Dun Pan
%A Xiaolei Zuo
%A Ying Wan
%A Lihua Wang
%A Jiong Zhang
%A Shiping Song
%A Chunhai Fan
%J Sensors
%D 2007
%I MDPI AG
%R 10.3390/s7112671
%X In this work, we reported a systematic investigation on the interactions betweenmethylene blue (MB) and surface-confined DNA by using electrochemical methods. Wedemonstrated that the redox potential of MB and binding and dissociation kinetics of MB toDNA differed significantly for single-stranded DNA (ss-DNA) and double-stranded DNA(ds-DNA) immobilized on gold electrodes. This was possibly due to the different bindingmechanism between MB and ss- or ds-DNA. This work might provide useful informationfor developing MB-based sequence-specific electrochemical DNA sensors.
%K Electrochemical DNA sensors
%K methylene blue
%K electrochemical indicators.
%U http://www.mdpi.com/1424-8220/7/11/2671