%0 Journal Article
%T Molecular genetic basis for the rhino mouse from Chinese KM subcolony
%A TIAN Ming
%A XIONG Yuliang
%A WANG Wanyu
%A ZHANG Yaping
%A <br>TIANMing
%A XIONGYuliang
%A WANGWanyu
%A ZHANGYaping
%J 科学通报(英文版)
%D 2004
%I 
%X Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia. Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology, skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.
%K KM mouse
%K shedding hair
%K mutation
%K rhino mouse
%K hairless (hr) gene<br>中国
%K 基因突变
%K 脱发症
%K 形态学
%K 组织病理学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=F98E2807FDC3E62B7A030DAAD4580973&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=0B39A22176CE99FB&sid=A020552C37306588&eid=04445C1D2BDA24EE&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=2&reference_num=43