%0 Journal Article
%T Establishment of widely expressed hb1f transgenic mouse lineage and its morphologic analysis
%A WANG Shuiliang
%A HE Yan
%A XIE Youhua
%A WANG Yuan
%A LI Jianzhong
%A WANG Long
%A WANG Zhugang
%A FU Jiliang
%A <br>WANGShuiliang
%A HEYan
%A XIEYouhua
%A WANGYuan
%A LIJianzhong
%A WANGLong
%A WANGZhugang
%A FUJiliang
%J 科学通报(英文版)
%D 2004
%I 
%X Human nuclear receptor hB1F is a novel member of the fushi tarazu factor I subfamily of nuclear receptor superfamily. The studies about its homologous genes indicate that hB1F may play a key role in regulating the metabolic homeostasis of cholesterol. After obtaining the founder mice carrying the transgene of hb1f by microinjection, each founder was mated to normal C57 mouse and the positive F1 by PCR identification of the same founder were intercrossed within sisters and brothers to establish the transgenic mouse lineage. The results of F1, F2 and offspring of test cross identification showed that the widely expressed hb1f transgenic mouse lineage was established successfully in this study. The tissue morphology of the transgenic lineage was also analyzed preliminarily.
%K human B1 binding factor (hB1F)
%K transgenic mouse
%K lineage establishment
%K phenotype analysis<br>脱氧核糖核酸
%K 转基因技术
%K 肝炎病毒
%K 形态学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=34B2CCBDC0645B8DF99FA0638AE600C5&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=0B39A22176CE99FB&sid=E22B6B8FE86DD8F9&eid=769BD58726D66E7D&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=20