%0 Journal Article
%T Epigenetic reprogramming in mammalian nuclear transfer
%A Shijie Li
%A Weihua Du
%A Ning Li
%A <br>LIShijie
%A DUWeihua
%A LINing
%J 科学通报(英文版)
%D 2004
%I 
%X Somatic cloning has been succeeded in some species, but the cloning efficiency is very low, which limits the application of the technique in many areas of research and biotechnology. The cloning of mammals by somatic cell nuclear transfer (NT) requires epigenetic reprogramming of the differentiated state of donor cell to a totipotent, embry-onic ground state. Accumulating evidence indicates that in-complete or inappropriate epigenetic reprogramming of do-nor nuclei is likely to be the primary cause of failures in nu-clear transfer. This review summarizes the roles of various epigenetic mechanisms, including DNA methylation, histone acetylation, imprinting, X-chromosome inactivation, te-lomere maintenance and expressions of development-related genes on somatic nuclear transfer.
%K somatic nuclear transfer
%K epigenetic reprogramming
%K DNA methylation
%K histon acetylation
%K X-chromosome activation
%K telomere
%K imprinting
%K gene expression<br>哺乳动物
%K 细胞核液迁移
%K 后成程序改编
%K DNA甲基化作用
%K 组蛋白
%K 乙酰化作用
%K X-染色体活化
%K 端粒
%K 印痕
%K 基因表达
%K 克隆
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=4D5889866A8FE03614D943BFBB1FFE1B&yid=D0E58B75BFD8E51C&vid=2A3781E88AB1776F&iid=5D311CA918CA9A03&sid=34A7AB0452E6AF23&eid=E3691231514F8E11&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=3&reference_num=75