%0 Journal Article
%T Direct measurement of compression spring constant of single DNA molecule with AFM
%A ZHOU Xingfei
%A AN Hongjie
%A GUO Yunchang
%A SUN Jielin
%A LI Minqian & HU Jun
%A <br>ZHOU Xingfei
%A AN Hongjie
%A GUO Yunchang
%A SUN Jielin
%A LI Minqian & HU Jun
%A .
%J 科学通报(英文版)
%D 2005
%I 
%X In this paper, a new approach is demonstrated to measure the compression elasticity of single biomolecule in small force regime (<0.5 nN) using vibrating mode scanning polarization force microscopy (VSPFM). With this method we investigate the compression elasticity of a single DNA molecule in the radial direction (perpendicular to DNA strands). The radial deformation of DNA molecules deposited on mica surface is shown to be able to reach about 50% un der external load, and this remarkable deformation is re- versible. In addition, the compression spring constant of DNA molecules is estimated to be about 0.6 nN/nm according to the height-force curves.
%K atomic force microscopy
%K single DNA molecule
%K elasticity<br>直接测量法
%K 弹性压缩
%K 单一生物分子
%K 显微镜方法
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=1ECED313F3CFC3D0F49797E1C593BA78&yid=2DD7160C83D0ACED&vid=771152D1ADC1C0EB&iid=F3090AE9B60B7ED1&sid=F5956B5D26BCB2A8&eid=158793AD8125C377&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=2&reference_num=21