%0 Journal Article
%T Interaction between en- dogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension<br>Interaction between endogenous nitric oxide and carbon monoxide in the pathogenesis of hypoxic pulmonary hypertension
%A SHI Yun
%A Du Junbao
%A GUO Zhiliang
%A ZENG Chaomei
%A TANG Chaoshu
%A <br>SHI Yun
%A DU Junbao
%A GUO Zhiliang
%A ZENG Chaomei & TANG Chaoshu
%J 科学通报(英文版)
%D 2003
%I 
%X The aim of the study was to investigate the in-teraction between nitric oxygenase (NOS)/ nitric oxide (NO) and heme oxygenase (HO)/ carbon monoxide (CO) system in the pathogenesis of hypoxic pulmonary hypertension. On a rat model of hypoxic pulmonary hypertension, the pulmo-nary artery pressure was measured, and NO formation and expression of NOS in pulmonary tissues were examined after treatment with ZnPP-IX, an HO-1 inhibitor. The pulmonary artery pressure, CO formation and expression of HO-1 in pulmonary tissues were examined after treatment with L-NAME, a NOS inhibitor. We found that pulmonary hy-pertension developed after 2-week hypoxia, while the con-centration of NO in the pulmonary tissue homogenates and the expression of NOS in intrapulmonary artery endothelial cells decreased markedly. ZnPP-IX worsened pulmonary hypertension of hypoxic rats. However, it increased endoge-nous production of NO and the expression of NOS obviously. The concentration of CO in the pulmonary tissue homoge-nates and the expression of HO-1 in intrapulmonary artery smooth muscle cells increased markedly with hypoxic pul-monary hypertension. L-NAME worsened pulmonary hy-pertension of hypoxic rats, but inhibited CO formation and HO-1 expression (P < 0.01). The results of this study sug-gested that endogenous NOS/NO and HO/CO systems might interact with each other and therefore play an important regulating role in hypoxic pulmonary hypertension.
%K carbon monoxide/metab
%K nitric oxide/ metab
%K hypoxia
%K hypertension
%K pulmonary/epidemiol<br>低氧
%K 肺源性高血压
%K 病理发生
%K 内源性NO
%K CO
%K 一氧化碳
%K 一氧化氮
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=353417245C5365243AA620AD8A65EC3E&yid=D43C4A19B2EE3C0A&vid=B6DA1AC076E37400&iid=CA4FD0336C81A37A&sid=7AA74D31F1FF2DCE&eid=869807E2D7BED9EC&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=4&reference_num=15