%0 Journal Article
%T FluxExplorer: A general platform for modeling and analyses of metabolic networks based on stoichiometry<br>FluxExplorer： A general platform for modeling and analyses of metabolic networks based on stoichiometry
%A Ruoyu Luo
%A Sha Liao
%A Shaoqun Zeng
%A Yixue Li
%A Qingming Luo
%A <br>LUO
%A Ruoyu
%A LIAO
%A Sha
%A ZENG
%A Shaoqun
%A LI
%A Yixue
%A LUO
%A Qingming
%J 科学通报(英文版)
%D 2006
%I 
%X Stoichiometry-based analyses of meta- bolic networks have aroused significant interest of systems biology researchers in recent years. It is necessary to develop a more convenient modeling platform on which users can reconstruct their network models using completely graphical operations, and explore them with powerful analyzing modules to get a better understanding of the properties of metabolic systems. Herein, an in silico platform, FluxExplorer, for metabolic modeling and analyses based on stoichiometry has been developed as a publicly available tool for systems biology research. This platform integrates various analytic approaches, in- cluding flux balance analysis, minimization of meta- bolic adjustment, extreme pathways analysis, shadow prices analysis, and singular value decom- position, providing a thorough characterization of the metabolic system. Using a graphic modeling process, metabolic networks can be reconstructed and modi- fied intuitively and conveniently. The inconsistencies of a model with respect to the FBA principles can be proved automatically. In addition, this platform sup- ports systems biology markup language (SBML). FluxExplorer has been applied to rebuild a metabolic network in mammalian mitochondria, producing meaningful results. Generally, it is a powerful and very convenient tool for metabolic network modeling and analysis.
%K metabolic network
%K flux balance analysis
%K computational modeling
%K systems biology<br>新陈代谢
%K 化学计量学
%K 系统生物学
%K 流量平衡分析
%K 计算模型
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=B267615FA7CEA78ACE8D6A2A416F3D7E&yid=37904DC365DD7266&vid=987EDA49D8A7A635&iid=B31275AF3241DB2D&sid=128B7AEF80A42C95&eid=A7379F6713A46835&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=1&reference_num=26