%0 Journal Article
%T Receptor role of membrane bound macrophage colony-stimulating factor<br>
%A Wu Kefu
%A He Zhihong
%A Zheng Guoguang
%A Rao Qing
%A Wang Xin
%A <br>
%J 科学通报(英文版)
%D 1998
%I 
%X According to the definition of cytokine, the direction of signaling should be from cytokine to receptor. The counter receptor was presented. Membrane bound macrophage colony-stimulating factor (m-M-CSF) and its receptor (M-CSF-R) were shown in human leukemic cell line J6-1 as autojuxtacrine mechanism. Soluble M-CSF receptor (sM-CSF-R), which was isolated from J6-1 cells membrane, was added into J6-1 cell culture. It was observed inhibition of J6-1 cell proliferation, decreasing of mitosis index and ratio of multinuclear cells, enlargement of cell diameter and volume, down regulation of numerous surface antigens. Dramatic change of intracellular pH was shown between several min to 20 min after treatment of sM-CSF-R. It suggested that some information was transmitted via m-M-CSF from sM-CSF-R. This counter signaling was not influenced by saccharification of m-MCSF.
%K cytokine
%K macrophage colony-stimulating factor
%K receptor
%K juxtacrine<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=6F84FFD6EDBF0BA851CEB7A8C865E442&yid=8CAA3A429E3EA654&vid=BE33CC7147FEFCA4&iid=59906B3B2830C2C5&sid=78996380F3108204&eid=78996380F3108204&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=10