%0 Journal Article
%T Signal transduction pathways mediated by colony stimulating factor-1 receptor<br>
%A Luo Shouqing
%A Zheng Dexian
%A <br>
%J 科学通报(英文版)
%D 1998
%I 
%X Colony-stimulating factor-1 (CSF-1), which is necessary for cell proliferation and differentiation, regulates both immediate and delayed early responses throughout G1 phase. The binding of CSF-1 to its receptor (CSF-1R) triggers phosphorylation of the receptor and its intrinsic tyrosine kinase. The activated receptor binds directly to cytoplasmic effector proteins, which induce multiple-signal transduction pathways. CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins. The expression of c-fos/jun family genes is also targeted following the activation of Ras. CSF-1R activates STAT1 and STAT3 to participate in signaling, but JAKs do not appear to contribute to signaling by CSF-1R. CSF-1R activates PI3-kinase, and PI3-ki can interact with downstream proteins by the MAPKK-related pathway independent of Ras/Raf. PC-PLC can enforce signaling in response to CSF-1. Furthermore, the turnover and dephosphorylation by the phosphatase SHPTP1 of CSF-1R are the major mechanism in the negative regulation of signaling by CSF-1R
%K colony stimulating factor-1 receptor
%K signal transduction
%K phosphorylation<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=DD6615BC9D2CFCE0B6F945E8D5314523&aid=0EC4EBFFC38886E35AFF917109255C03&yid=8CAA3A429E3EA654&vid=BE33CC7147FEFCA4&iid=59906B3B2830C2C5&sid=CF2C3194F1B66D28&eid=CF2C3194F1B66D28&journal_id=1001-6538&journal_name=科学通报(英文版)&referenced_num=0&reference_num=31