%0 Journal Article
%T Synthesis and Antimicrobial Activity of Some New Quinoxaline Derivatives
%A Dharmchand Prasad Singh
%A Sanjay Kumar Deivedi
%A Syed Riaz Hashim
%A Ram Gopal Singhal
%J Pharmaceuticals
%D 2010
%I MDPI AG
%R 10.3390/ph3082416
%X 2-Chloro-3-methylquinoxaline was selected as a nucleus around which various molecular transformations were performed to obtain new compounds expected to possess optimized antimicrobial activity. As very little work regarding attachment of ether linkages replacing chlorine at C-2 has been reported, it was thought worthwhile to synthesize various quinoxaline derivatives by replacing the C 2 chlorine with an ether linkage attached to a benzene ring possessing an aldehyde or a free amino group which can be further reacted with aromatic amines and aromatic aldehydes, respectively, to yield new Schiff bases containing quinoxaline moieties. Thus the compounds 4-(2-methylquinoxalinyloxy) benzaldehyde ( 4), 2-[4-(substituted-benziminomethyl)-phenoxy]-3-methyl quinoxalines 5a¨Ce, 4-(2-methyl-quinoxaline-3-yloxy)benzamine ( 6) and 4-(2-methylquinoxalin-3-yloxy)- N-substituted benzylidine benzamines 7a¨Ce were synthesized and tested for their antimicrobial activity. The structures of the compounds were confirmed on the basis of their elemental and spectral data.
%K quinoxalines
%K benzamine
%K benzaldehyde
%K antimicrobial activity
%U http://www.mdpi.com/1424-8247/3/8/2416