%0 Journal Article
%T Acid-Sensing Ion Channels and Pain
%A Qihai Gu
%A Lu-Yuan Lee
%J Pharmaceuticals
%D 2010
%I MDPI AG
%R 10.3390/ph3051411
%X Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
%K acid sensing ion channel
%K acidosis
%K inflammation
%K nociceptor
%K pain
%U http://www.mdpi.com/1424-8247/3/5/1411