%0 Journal Article
%T Synthesis and Reactions of Some New Heterocyclic Carbohydrazides and Related Compounds as Potential Anticancer Agents
%A Abdel Kader Mansour
%A Mohga M. Eid
%A Nasser S. A. M. Khalil
%J Molecules
%D 2003
%I MDPI AG
%R 10.3390/81000744
%X Acylation of 3-hydrazino-5,6-diphenyl-1,2,4-triazine (2) and hydrazine hydrate (7) with 4-aryl-1,3,7-triphenyl-8-oxa-1,2,6-triazaspiro[4.4]nona-2,6-dien-9-ones 5a,b gave the corresponding heterocyclic carbohydrazides 6a,b and 8a,b respectively. Conversion of compounds 8a,b into the versatile carbohydrazide derivatives 9a-g, 10, 13 and the related oxadiazoles 11, 12a,b was undertaken. A primary in vitro test of compound 8a (concentration 10-4 M) showed activity against leukemia cell lines (CCRFCEM, K-256, MOLT-4, PRMI-8226, SR).
%K Synthesis
%K Pyrazoles
%K 2-Pyrazolines
%K Carbohydrazides
%U http://www.mdpi.com/1420-3049/8/10/744