%0 Journal Article
%T Novel 4-Aroyl-3-alkoxy-2(5H)-furanones as Precursors for the Preparation of Furo[3,4-b][1,4]-diazepine Ring System
%A Hans Zimmer
%A Christian P. Librera
%A Sven Hausner
%A Jeanette Bauer
%A Adel Amer
%J Molecules
%D 2003
%I MDPI AG
%R 10.3390/81000735
%X A general synthesis of tetronic acid derivatives, namely 4-aroyl-3-alkoxy-2(5H)-furanones, is achieved via the treatment of an anhydrous dimethylformamide (DMF) solution of 4-aroyl-3-hydroxy-2(5H)-furanones with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as base at -10-0ˇăC, followed by the addition of alkyl iodide. Their structural assignments are based on spectroscopic data and confirmed by X-ray crystallography. These furanones were used as starting materials for the preparation of furodiazepines.
%K 4-Aroyl-3-alkoxy-2(5H)-furanones
%K 7-aryl-4
%K 5-dihydro-2-oxo-3H
%K 8H-furo- [3
%K 4-b][1
%K 4]diazepines
%K X-ray structures
%U http://www.mdpi.com/1420-3049/8/10/735