%0 Journal Article
%T 2-(p-Hydroxybenzyl)indoles - Side Products Formed Upon Cleavage of Indole Derivatives from Carboxylated Wang Polymer - an NMR Study
%A Felikss Mutulis
%A M¨˘t¨¦ Erd¨¦lyi
%A Ilze Mutule
%A Jana Kreicberga
%A Sviatlana Yahorava
%A Aleh Yahorau
%A Larisa Borisova-Jan
%A Jarl E.S. Wikberg
%J Molecules
%D 2003
%I MDPI AG
%R 10.3390/81000728
%X Treatment of carboxylated Wang polymer attached to a 2-unsubstituted indole derivative with a trifluoroacetic acid based mixture resulted in a side reaction: p-hydroxybenzylation at the 2-position of the indole ring. The structure of the resulting N-3-aminopropyl)-N-benzyl-4-[2-(4-hydroxybenzyl)-1H-indol-3-yl]-butyramide trifluoroacetate was ascertained by a full assignment of its 1H- and 13C-NMR spectra. The side reaction could be suppressed by the use of 1,2-ethanedithiol in high concentrations (16 %).
%K Carboxylated Wang polymer
%K side reaction
%K p-hydroxybenzylation
%K 1
%K 2-ethanedithiol
%K NMR
%U http://www.mdpi.com/1420-3049/8/10/728