%0 Journal Article
%T Side-chain Modifications of Highly Functionalized 3(2H)-Furanones
%A Viviani Nardini
%A Shirley Muniz Machado Rodrigues
%A Maur¨ªcio Gomes Constantino
%A Gil Valdo Jos¨¦ da Silva
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules171012151
%X A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
%K 3(2H)-furanone
%K isoxazole
%K natural products
%K side-chain modifications
%U http://www.mdpi.com/1420-3049/17/10/12151