%0 Journal Article
%T Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals
%A Chong-En Xu
%A Meng-Yuan Zhang
%A Cheng-Wei Zou
%A Ling Guo
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules17089070
%X Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-¦Á (TNF-¦Á), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-¦Á, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.
%K oxidative injury
%K SOD
%K ulinastatin
%K AST
%K LDH
%K NO
%U http://www.mdpi.com/1420-3049/17/8/9070