%0 Journal Article
%T p-Cymene Protects Mice Against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammatory Cell Activation
%A Guanghong Xie
%A Na Chen
%A Lanan Wassy Soromou
%A Fang Liu
%A Ying Xiong
%A Qianchao Wu
%A Hongyu Li
%A Haihua Feng
%A Guowen Liu
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules17078159
%X The objective of this study was to test the hypothesis that p-cymene can attenuate acute lung injury induced by lipopolysaccharide (LPS) in vivo. In the mouse model of LPS-induced acute lung injury, intraperitoneal preconditioning with p-cymene resulted in a significant reduction of pro-inflammatory cytokines (TNF-¦Á, IL-1¦Â and IL-6), lung water gain, in£¿ammatory cell in£¿ltration, lung tissue myeloperoxidase activity. In addition, p-cymene blocked the phosphorylation of I¦ÊB¦Á protein and mitogen-activated protein kinases (MAPK) signaling pathway activation. Histopathologic examination of lung tissue indicated that p-cymene treatment markedly decreased focal thickening, congestion, pulmonary edema, and inflammatory cells infiltration. The results showed that p-cymene had a protective effect on LPS-induced ALI in mice.
%K p-cymene
%K lipopolysaccharide
%K acute lung injury
%U http://www.mdpi.com/1420-3049/17/7/8159