%0 Journal Article
%T Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
%A Yue Zhou
%A Peilin Yu
%A Hongwei Jin
%A Zhenjun Yang
%A Jianbo Yue
%A Liangren Zhang
%A Lihe Zhang
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules17044343
%X Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed H¨¹isgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation. Preliminary biological investigations showed that these cADPR mimics are membrane-permeating agonists of the calcium signaling pathway. The introduction of chlorine or fluorine at the 2'-position of the southern riboses led to a decrease of activity. The existence of a hydrophobic group on the 3'-OH of the southern riboses does not obviously alter the agonistic activity.
%K cADPR analogue
%K nucleotide
%K synthesis
%K calcium mobilization
%U http://www.mdpi.com/1420-3049/17/4/4343