%0 Journal Article
%T Synthesis and Herbicidal Activity Evaluation of Novel ¦Â-Carboline Derivatives
%A Qunfang Weng
%A Jingfei Huang
%A Yong Zeng
%A Yueye Deng
%A Meiying Hu
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules17043969
%X Based on the original structure of harmine, several novel 1,2,3,4-tetrahydro-¦Â-carboline, ¦Â-carboline and 1-substituted-¦Â-carboline derivatives bearing a substituted carbohydrazide group at C-3 were designed and synthesized to investigate the structure-activity relationship of their analogues. All of the compounds were characterized by infrared (IR), proton and carbon nuclear magnetic resonance (1H-NMR, 13C-NMR), and mass spectroscopy (MS). The bioassay tests showed that N'-benzylidene-1-phenyl-¦Â-carboline-3-carbohydrazide (C25H18N4O, m.w. 390.4) (c2) and N'-(4-trifluoromethyl-benzylidene)-1-phenyl-¦Â-carboline-3-carbohydrazide (C26H17N4OF3, m.w. 458) (d2) exhibited good inhibitory activity against dicotyledonous and monocotyledonous weeds, with EC50 values of 4.83 ¦ÌM and 14.25 ¦ÌM, respectively.
%U http://www.mdpi.com/1420-3049/17/4/3969