%0 Journal Article
%T Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents
%A Shang-Shing P. Chou
%A Jui-Chi Juan
%A Shwu-Chen Tsay
%A Kuei Pin Huang
%A Jih Ru Hwu
%J Molecules
%D 2012
%I MDPI AG
%R 10.3390/molecules17033370
%X Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.
%K photo-induced DNA-cleavage
%K oxime esters
%K 2
%K 6-diazaanthracene-9
%K 10-dione
%K 4
%K 5-diazafluoren-9-one
%U http://www.mdpi.com/1420-3049/17/3/3370