%0 Journal Article
%T Chemical constituents and antitumor activity of fruiting body of Fomes fomentarius<br>木蹄层孔菌子实体化学成分及对肿瘤细胞的抑制作用的研究
%A HUANG Tian-Zi
%A DU De-Yao
%A CHEN Yong-Qiang
%A YUAN Bo
%A JU Xiu-Yun
%A FENG You-Jian
%A WANG Li
%A JIANG Ji-Hong
%A <br>黄天姿
%A 杜德尧
%A 陈永强
%A 袁博
%A 鞠秀云
%A 冯友建
%A 王力
%A 蒋继宏
%J 菌物学报
%D 2012
%I 
%X The compounds from the EtOH-extract of Fomes fomentarius were isolated and purified by using silicagel and Sephadex LH-20 column chromatography. NMR, MS and other spectroscopy were used to identify the structures of compounds. Twelve compounds were determined: ergosta-7,22-dien-3-palmitate (1), stearic acid (2), palmitic acid (3), ergosta-7,22-dien-3-one (4), ergosta-7,22-dien-3-ol (5), 5,8-epidioxyergosta-6,22-dien-3-ol (6), ergosta-7,22-dien-3- one,dimethyl acetal (7), lup-20(29)-ene-3,28-diol,28-acetate (8), betulin (9), 3-hydroxyoctadecanoic acid (10), 9,10- dihydroxystearic acid (11), daphnetin (12). The anti-tumor activities against NCI-H 460 and SGC-7901 were evaluated by Alamar Blue method, and the results showed that compound 4 had the highest antitumor activity against NCI-H 460 and compound 9 against SGC-7901.
%K Fomes fomentarius
%K chemical constituent
%K NCI-H 460
%K SGC-7901
%K daphnetin<br>木蹄层孔菌
%K 化学成分
%K 人肺癌细胞NCI-H
%K 460
%K 人胃癌细胞SGC-7901
%K 瑞香素
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=CA9F815FCB0F62294C4266BB6F902ACB&aid=2350B5576F89D072698DD87567AA4AF3&yid=99E9153A83D4CB11&vid=4AD960B5AD2D111A&iid=94C357A881DFC066&sid=FA519F4FF622280A&eid=839A12D3ACF8C715&journal_id=1672-6472&journal_name=菌物学报&referenced_num=0&reference_num=0