%0 Journal Article
%T Effects of medicinal ossified Catharsius molossus on in vitro anti-tumor activity of Ganoderma lucidum fermented products<br>药用昆虫蜣螂对灵芝发酵产物体外抗肿瘤活性的影响
%A LIU Gao-Qiang
%A DING Chong-Yang
%A ZHANG Ke-Chang
%A <br>刘高强
%A 丁重阳
%A 章克昌
%J 菌物学报
%D 2008
%I 
%X 采用体外高通量筛选技术检测了补加药用昆虫蜣螂前后灵芝发酵产物的体外抗肿瘤活性.结果表明,补加和不补加蜣螂发酵后所得的胞内和胞外三萜样品对肉瘤细胞L290、肠癌细胞SW620、血癌细胞K562和肝癌细胞BEL7402都有显著的抑制作用(P＜0.05).在补加蜣螂发酵后,灵芝胞内三萜的抑制作用没有得到增强:但胞外三萜样品对BEL7402细胞的抑制作用得到了增强,补加和不补加蜣螂发酵后所得胞外三萜的抑制率分别为41.74%和32.37%(P＜0.05).由于补加蜣螂发酵后,新生成了胞外三萜Iucidone C,因而对Iucidone C的抗BEL7402肝癌活性进行了试验.结果显示,lucidone C在100ug/mL时,对BEL7402的抑制率为50.37%,提示lucidone C可能增强了补加蜣螂后灵芝胞外总三萜对BEL7402细胞的抑制作用.
%K medicinal fungus
%K traditional Chinese medicine (TCM)
%K medicinal insects
%K anti-cancer action<br>药用真菌
%K 中药
%K 药用昆虫
%K 抗癌作用
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=CA9F815FCB0F62294C4266BB6F902ACB&aid=23C63720F3726537F89B512764B03DB8&yid=67289AFF6305E306&vid=DB817633AA4F79B9&iid=B31275AF3241DB2D&sid=5357CC5E80802025&eid=8115E88DD41C4B46&journal_id=1672-6472&journal_name=菌物学报&referenced_num=1&reference_num=21