%0 Journal Article
%T High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
%A Thierry Juspin
%A Laura Zink
%A Maxime D. Crozet
%A Thierry Terme
%A Patrice Vanelle
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16086883
%X We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)-phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthylen-1(2H)-one from the reactions of 4-[4-(chloromethyl)phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and a-carbonyl ester derivatives using tetrakis(dimethylamino)ethylene (TDAE) methodology.
%K TDAE
%K 5-nitro-1H-imidazole
%K arylethanol
%K carbonyl derivatives
%U http://www.mdpi.com/1420-3049/16/8/6883