%0 Journal Article
%T Microwave Assisted Organic Synthesis (MAOS) of Small Molecules as Potential HIV-1 Integrase Inhibitors
%A Stefania Ferro
%A Sara De Grazia
%A Laura De Luca
%A Rosaria Gitto
%A Caterina Elisa Faliti
%A Zeger Debyzer
%A Alba Chimirri
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16086858
%X Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development of some three-dimensional pharmacophore models which have led to the identification of a large series of potent HIV-1 integrase strand-transfer inhibitors (INSTIs) bearing an indole core. To gain a better understanding of the structure-activity relationships (SARs), herein we report the design and microwave-assisted synthesis of a novel series of 1-H-benzylindole derivatives.
%K AIDS
%K integrase inhibitors
%K small molecules
%K MAOS
%U http://www.mdpi.com/1420-3049/16/8/6858