%0 Journal Article
%T Synthesis under Microwave Irradiation of [1,2,4]Triazolo[3,4-b]£¿[1,3,4]thiadiazoles and Other Diazoles Bearing Indole Moieties and Their Antimicrobial Evaluation
%A Sobhi M. Gomha
%A Sayed M. Riyadh
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16108244
%X Microwave-assisted synthesis of some novel compounds, namely, 3-(2-methyl-1H-indol-3-yl)-6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles 5a,b was accomplished via bromination of 2-methyl-3-[4-(arylideneamino)-5-mercapto-4H-[1,2,4]triazol-3-yl]-1H-indoles 3a,b. Also, new [1,3,4]thiadiazoles 12a,b, [1,2,4]triazoles 15a,b and [1,3,4]oxadiazoles 19a,b, with indole moieties, were prepared by cyclization of 1-[(2-methyl-1H-indole)-3-carbonyl]thiosemicarbazides 8a,b under microwave irradiation using different reaction conditions. Moreover, reaction of acid hydrazide 7 with ethyl 2-(N-phenylhydrazono)-3-oxobutanoate (20) gave the respective phenylhydrazonopyrazole derivative 21 under the reaction conditions employed. The structures of the synthesized compounds were assigned based on elemental analyses and spectral data (IR, 1H-NMR, 13C-NMR, MS). The antifungal and antibacterial activities of the new products were also evaluated.
%K [1
%K 2
%K 4]triazolo[3
%K 4-b][1
%K 3
%K 4]thiadiazoles
%K diazoles
%K Schiff¡¯s bases
%K microwave irradiation and antimicrobial activity
%U http://www.mdpi.com/1420-3049/16/10/8244