%0 Journal Article
%T Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B
%A Seung-Mann Paek
%A Young-Ger Suh
%J Molecules
%D 2011
%I MDPI AG
%R 10.3390/molecules16064850
%X Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile procedure for the construction of the macrolactone skeleton of macrosphelide B in terms of facial selectivity. Our preliminary and unprecedented stereoselective procedure is anticipated to be usefully applied through further studies for the synthesis of the macrosphelide family.
%K intramolecular nitrile oxide cycloaddition
%K macrosphelide
%K polyketide
%K total synthesis
%K phase transfer catalyst
%U http://www.mdpi.com/1420-3049/16/6/4850