%0 Journal Article
%T Effect of Aggressive Early High-Dose Intravenous Amino Acid Infusion and Early Trophic Enteral Nutrition on Very Low Birth Weight Infants
%A Man-Yau Ho
%A Yu-Hsuan Yen
%A Hsiang-Yin Chen
%A Shu-Chen Chien
%A Mao-Chih Hsieh
%A Yao-Shun Yang
%J Food and Nutrition Sciences
%P 1604-1608
%@ 2157-9458
%D 2012
%I Scientific Research Publishing
%R 10.4236/fns.2012.311209
%X Objective: Very-low-birth-weight (VLBW) preterm infants are at risk of growth delay if they do not receive adequate nutritional support. This study evaluated the effect of aggressive early high-dose amino acid infusion plus early enteral trophic feeding on growth in VLBW infants within the first day of life. Study Design: The effect of a high-dose 3 g amino acid (HAA)/kg/d regimen beginning on the first day of life was compared with that of low-dose amino acid (LAA) supplementation at a dose of 0.5 or 1.0 g/kg/d. The primary outcome measures were the days of regained birth weight and achieved full enteral feeding. Result: Compared with the 19 infants in the LAA group, the 17 infants in the HAA group achieved significantly earlier full enteral feeding (7.8 ¡À 3.6 vs. 15.2 ¡À 8.9, p = 0.003) and regained birth weight (13.3 ¡À 3.8 vs. 17.5 ¡À 7.9, p = 0.047). In addition, shorter parenteral nutrition time was achieved by HAA administration (p < 0.05). Total energy intake was greater during the first 7 days of life in the HAA group (85 ¡À 12 kcal/kg/d on day 7) than in the LAA group (60 ¡À 16 kcal/kg/d on day 7, p < 0.001). Other clinical parameters such as length of hospital stay and morbidity favored the use of HAA. Conclusion: Aggressive early simultaneous amino acid administration plus enteral feeding during the first few days of life for preterm infants was associated with improved weight gain and earlier full enteral feeding.
%K Early Nutrition
%K Trophic Enteral Feeding
%K Very Low Birth Weight
%K Preterm Infant
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=24699