%0 Journal Article
%T Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa
%A Ying Xu
%A Jun-Hui Lang
%A Wei-Hua Jiao
%A Ru-Ping Wang
%A Ying Peng
%A Shao-Jiang Song
%A Bao-Hua Zhang
%A Hou-Wen Lin
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10071445
%X Seven new formamido-diterpenes, cavernenes A每D ( 1每 4), kalihinenes E and F ( 5每 6), and kalihipyran C ( 7), together with five known compounds ( 8每 12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small panel of human cancer cell lines (HCT-116, A549, HeLa, QGY-7701, and MDA-MB-231) with IC 50 values in the range of 6每18 米M. In addition, compound 9 showed weak antifungal activity against Trichophyton rubrum and Microsporum gypseum with MIC values of 8 and 32 米g/mL, respectively, compound 10 displayed weak antifungal activity against fungi Candida albicans, C ryptococcus neoformans, T. rubrum, and M. gypseum with MIC values of 8, 8, 4, and 8 米g/mL, respectively.
%K Acanthella cavernosa
%K formamido-diterpenes
%K cytotoxicity
%K antifungal activity
%U http://www.mdpi.com/1660-3397/10/7/1445