%0 Journal Article
%T Understanding the “Horizontal Dimension” of Molecular Evolution to Annotate, Classify, and Discover Proteins with Functional Domains<br>Understanding the "Horizontal Dimension'''' of Molecular Evolution to Annotate, Classify, and Discover Proteins with Functional Domains
%A Gloria Rendon
%A Mao-Feng Ger
%A Ruth Kantorovitz
%A Shreedhar Natarajan
%A Jeffrey Tilson
%A Eric Jakobsson
%A <br>Gloria Rendon
%A Mao-Feng Ger
%A Ruth Kantorovitz
%A Shreedhar Natarajan
%A Jeffrey Tilson
%A Eric Jakobsson
%J 计算机科学技术学报
%D 2010
%I 
%X Protein evolution proceeds by two distinct processes: 1) individual mutation and selection for adaptive mutations and 2) rearrangement of entire domains within proteins into novel combinations, producing new protein families that combine functional properties in ways that previously did not exist. Domain rearrangement poses a challenge to sequence alignment-based search methods, such as BLAST, in predicting homology since the methodology implicitly assumes that related proteins primarily differ from each ot...
%K domain-based discovery
%K domain-based orthology
%K domain interactions
%K InterPro
%K MEME/MAST<br>蛋白质结合
%K 分子进化
%K 功能域
%K 适应性突变
%K 蛋白质相互作用
%K 计算生物学
%K 注释
%K 分类
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=5B3AB970F71A803DEACDC0559115BFCF0A068CD97DD29835&cid=8240383F08CE46C8B05036380D75B607&jid=F57FEF5FAEE544283F43708D560ABF1B&aid=935DDE529CC65D9387AF71AD98E564A4&yid=140ECF96957D60B2&vid=C5154311167311FE&iid=CA4FD0336C81A37A&sid=0D0D661F0B316AD5&eid=BB0EA31DB1B01173&journal_id=1000-9000&journal_name=计算机科学技术学报&referenced_num=0&reference_num=72