%0 Journal Article
%T Aurantoside K, a New Antifungal Tetramic Acid Glycoside from a Fijian Marine Sponge of the Genus Melophlus
%A Rohitesh Kumar
%A Ramesh Subramani
%A Klaus-D. Feussner
%A William Aalbersberg
%J Marine Drugs
%D 2012
%I MDPI AG
%R 10.3390/md10010200
%X A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis ( 1H NMR, 1H¨C 1H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant activity in antimalarial, antibacterial, or HCT-116 cytotoxicity assays, but exhibited a wide spectrum of antifungal activity against wild type Candida albicans, amphotericin-resistant C. albicans, Cryptococcus neoformans, Aspergillus niger, Penicillium sp ., Rhizopus sporangia and Sordaria sp .
%K marine sponges
%K aurantosides
%K antifungal
%K tetramic acid glycoside
%K Melophlus sp.
%U http://www.mdpi.com/1660-3397/10/1/200